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Introduction to PBMC for cell immunotherapy
Introduction to PBMC for cell immunotherapy
PBMC is an abbreviation for peripheral blood mononuclear cells. Note that here is the mononuclear cell, not the Monocyte monocyte, which refers to any peripheral blood cell that has a rounded nucleus. That is to say, PBMC is an immune lymphocyte derived from the blood of healthy animals.
These cells include lymphocytes (T cells, B cells, NK cells) and monocytes, and granulocytes (including neutrophils, basophils, and eosinophils) have multi-lobed nuclei, sometimes it is divided into this category [1].
Therefore, PBMC is not a kind of cell, but a mixed immune cell. And immune cells are the most important soldiers in the body against viral diseases. Lymphocytes, monocytes, and Neutrophil Granulocytes in PBMC have very strong anti-tumor (cancer cells) and anti-viral effects!
However, T cells and NK (Natural Killer) cells are most important lymphoid in PBMC.
Read more: Introduction to PBMC for cell immunotherapyPD-1 免疫治療方式
以下全文轉載自東周網2018年12月16日發佈的文章
PD-1免疫治療在2011年開始在人類治療癌症中應用,李恆年獸醫認為其治療原理如剎車系統。PD-1其實是一種細胞外層的蛋白質,它原本的功能是讓免疫系統不攻擊某些良好細胞,但是腫瘤會偽裝成良好的細胞,發放出PDL-1這種細胞與PD-1結合,利用PD-1的特色讓免疫系統中的T細胞不能正常殺死腫瘤。
Read more: PD-1 免疫治療方式